Monday, December 1, 2014

Conclusion and References

         Caffeine, as an independent substance, poses some beneficial effects and also exhibits tolerance and some withdrawal symptoms. However, these are relatively mild in comparison to other drugs. As for the pharmacology of the substance, caffeine acts as a non-selective "brake" against adenosine acting on it’s receptors. We can conclude that the major risk of caffeine consumption is actually the combination of its reinforcing effects with the products in which it can be found, such as energy drinks, soda and other generally unhealthy items.

References:
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 Al-Saleh, I., Coskun S., El-Doush, I., Grisellhi, B. (2010) The effect of caffeine consumption on the success rate of pregnancy as well various performance parameters of in-vitro fertilization treatment.  Med Sci Monit, 16(12): CR598-605

 Arendasha,G., Caoa, C., Cintron, B., Dicksona, A., Echeverriaf, V., Lina, X., Mamcarza, M., Moric, T., Pottera, H., Rezai-Zadehe, K., Runfeldta, M., Tane, J. (2009) Caffeine Reverses Cognitive Impairment and Decreases Brain Amyloid-β Levels in Aged Alzheimer’s Disease Mice. Journal of Alzheimer’s Disease (17)661–680

Balkin, T., Kamimori, G., Laxminarayan, S., Ramakrishnan, S., Reifman, J., Wesensten, N. (2009). Dose-dependent model of caffeine effects on human vigilance during total sleep deprivation. Journal of Theoretical Biology 358:11–24
 Bara, A., Barley, E., Cates C., Welsh, E. (2011) Caffeine for asthma (Review). The Cochrane Library(10)

Better, W., Cadet, J., Griffiths, R., Herning, R., Sigmon, S. (2009). Caffeine withdrawal, acute effects, tolerance, and absence of net beneficial effects of chronic administration: cerebral blood flow velocity, quantitative EEG, and subjective effects. Psychopharmacology204(4), 573-585.

 Birkett, D., Lelo, A., Miners, J. O., Robson, R., (1986). Assessment of caffeine exposure: Caffeine content of beverages, caffeine intake, and plasma concentrations of methylxanthines. Clinical pharmacology and therapeutics39(1), 54-59      
                                         
 Budney, A., Brown, P., Griffiths, R., Hughes, J., Juliano, L. (2013) Caffeine Withdrawal and Dependence: A Convenience Survey Among Addiction Professionals.  Journal of Caffeine Research, 3(2): 67-71

Brunya, T., Giles, G., Lieberman, H., Mahoney, C., Taylor, H. (2010). Acute caffeine consumption enhances the executive control of visual attention in habitual consumers. Brain and Cognition74(3), 186-192

Chu, Y., Joseph, J., Lyle, B., Miller, M., Shukitt, B. (2013). Coffee, but not caffeine, has positive effects on cognition and psychomotor behavior in aging. Age35(6), 2183-2192.

 Costenla, A., Cunhab, R., de Mendonca, A. (2010) Caffeine, Adenosine  Receptors, and Synaptic Plasticity. Journal of Alzheimer’s Disease, 20: S25–S34

Derry, C., Derry, S., Moore, R. (2012) Caffeine as an analgesic adjuvant for acute pain in adults. Cochrane Database of Systematic Reviews, Issue 3. Art. No.: CD009281. DOI:10.1002/14651858.CD009281.pub2.

Griffiths, R. Juliano, L. (2004). A critical review of caffeine withdrawal: empirical validation of symptoms and signs, incidence, severity, and associated features . Psychopharmacology176(1), 1-29. Retrieved April 8, 2011, from http://dx.doi.org/10.1007/s00213-004-2000-x

Griffiths, R., Reissig, C., Strain, E.(2009). Caffeinated energy drinks - a growing problem. Drug and Alcohol Dependence99(1-3), 1-10. Retrieved May 25, 2012, from http://dx.doi.org/10.1016/j.drugalcdep.2008.08.001

 Pohler, H. (2010). Caffeine Intoxication And Addiction. The Journal for Nurse Practitioners6(1), 49-52.

Ruxton, C. (2012). Health Aspects of Caffeine: Benefits and Risks. Taking Sides: Clashing Views on Controversial Issues in Drugs and Society, 10:245-255

Satel, S. (2006). Is Caffeine Addictive?  A Review Of The Literature. The American Journal of Drug and Alcohol Abuse32(4), 493-502.

Smith, A. (2002). Effects of caffeine on human behavior. Food and Chemical Toxicology40(9), 1243-1255.

Temple, J. (2009). Caffeine Use In Children: What We Know, What We Have Left To Learn, And Why We Should Worry. Neuroscience & Biobehavioral Reviews33(6), 793-806.
Yang, A., Palmer, A. A., & Wit, H. (2010). Genetics of Caffeine Consumption And Responses To Caffeine. Psychopharmacology211(3), 245-257.




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